Sleep apnea and effect of chemostimulation on breathing instability in mice 

作成者 中村, 晃, 福田, 康一郎, 桑木, 共之
作成者の別表記 Nakamura, Akira, Fukuda, Yasuichiro, Kuwaki, Tomoyuki
キーワード等 sleep apnea syndromes, respiration, control of breathing, whole body plethysmography
日本十進分類法 (NDC) 490
内容 Sleep apnea occurs in humans and experimentalanimals. We examined whether it also arises inadult mice. Ventilation in male adult 129/Sv mice was recordedconcomitantly by electroencephalograms and electromyogramsfor 6 h by use of body plethysmography. Apneawas defined as cessation of plethysmographic signals forlonger than two respiratory cycles. While mice breathed roomair, 32.3+-6.9 (mean+-SE, n=5) apneas were observedduring sleep but not in quiet awake periods. Sleep apneaswere further classified into two types. Postsigh apneas occurredexclusively during slow-wave sleep (SWS), whereasspontaneous apneas arose during both SWS and rapid eyemovement sleep. Compared with room air (9.1+-1.4/h ofSWS), postsigh apneas were more frequent in hypoxia(13.7+-2.1) and less frequent in hyperoxia (3.6+-1.7) andhypercapnia (2.8+-2.1). Our data indicated that significantsleep apnea occurs in normal adult mice and suggested thatthe mouse could be a promising experimental model withwhich to study the genetic and molecular basis of respiratoryregulation during sleep.
コンテンツの種類 雑誌掲載論文 Journal Article
DCMI資源タイプ text
ファイル形式 application/pdf
掲載誌情報 Journal of Applied Physiology Vol.94 no.2 page.525-532 (200302)
言語 英語

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