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A STUDY ON THE CONSTITUENTS AND STRUCTURE ELUCIDATION OF INDOLE ALKALOIDS FROM GELSEMIUM ELEGANS BENTH. IN THAILAND 

作成者 Wongseripipatana, Sumphan
日本十進分類法 (NDC) 430, 470
内容 抄録:The roots, stems and branches, leaves and seeds of Gelsemium elegans Benth. have been investigated for alkaloids. Sixteen alkaloids have been isolated and characterized. There are seven new alkaloids, three of them have been identified-as indole alkaloids 16-epi-voacarpine, 19-(Z)-taberpsychine, and koumine Noxide; the other being oxindole alkaloids identified as 19-hydroxydihydrogelsevirine, elegansamine, gelsemine N-oxide and 19-oxogelsenicine. Included are three known indole alkaloids koumine, 19-(Z)-akuammidine and koumidine, and six known oxindole alkaloids gelsemine, gelsevirine, gelsenicine (humantenmine), 14-hydroxygelsenicine (humantenidine), humantenine and 14-hydroxygelsedine, The structures of two known alkaloids, koumidine and 19-(Z)-akuammidine have been revised to (19Z)-form. Among seven new alkaloids, three bases 19-(Z)-taberpsychine, 19-hydroxydihydrogelsevirine and 16-epi-voacarpine were found from the roots; two alkaloids 16-epi-voacarpine and elegansamine were isolated from the stems and branches without leaves; four alkaloids koumine N-oxide, gelsemine N-oxide, 19-oxogelsenicine, and 16-epi-voacarpine were obtained from the leaves. The seeds of this plant contain only known alkaloid, 14-hydroxygelsedine. Furthermore, partial synthesis and absolute configuration determination of koumidine and 19-(Z)-taberpsychine have been carried out. The formal synthesis of koumine and the biogenetic route of Gelsemium alkaloids have been proposed and discussed in this thesis.
学位:千大院薬博乙第75号

寄与者 千葉大学大学院薬学研究院
コンテンツの種類 博士論文 Doctoral Thesis
DCMI資源タイプ text
ファイル形式 application/pdf
ハンドルURL http://mitizane.ll.chiba-u.jp/meta-bin/mt-pdetail.cgi?cd=00022625
フルテキストへのリンク http://mitizane.ll.chiba-u.jp/metadb/up/assist1/Y_O-006.pdf
言語 英語
著者版フラグ author


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