同種造血幹細胞移植後の白血病再発率減少におけるIL-12の役割.   :   Role of IL-12 in reducing the rate of leukemic relapse after allogeneic stem cell transplantation 

作成者 清水, 直美, 西村, 美樹, 中世古, 知昭, 浅井, 隆善, 齋藤, 康
作成者 (ヨミ) シミズ, ナオミ, ニシムラ, ミキ, ナカセコ, チアキ, アサイ, タカヨシ, サイトウ, ヤスシ
作成者の別表記 Shimizu, Naomi, Nishimura, Miki, Nakaseko, Chiaki, Asai, Takayoshi, Saito, Yasushi
キーワード等 Allo-SCT, immunotherapy, GVHD, GVL, IL-12
日本十進分類法 (NDC) 490
内容 14人, II度以上6人, 慢性GVHDの発症はLimited型6人, Extensive型13人であった。移植後完全寛解を維持している患者は再発群に比しIL-12が高い傾向にあった。IL-12と急性GVHD, 慢性GVHDとの関連は見られなかった。同種造血幹細胞移植後免疫療法を受けた9人で, 治療後血液学的寛解を1年以上維持した有効群3人で無効群に比し, 有意差を持ってIL-12の上昇を認め, 有効群ではIL-12の高値が数ケ月間維持された。また, 免疫療法後, 慢性GVHDの発症群6例で有意なIL-12の上昇を認めた。同種造血幹細胞移植後の抗白血病効果に関する免疫反応に, IL-12の関与が示唆された。
IL-12 is an important cytokine for regulation of immunoreactions. To investigate the relation between IL-12 and the GVL effect after allo-SCT, we measured serum concentrations of IL-12 of 39 consecutive allo-SCT recipients including 9 patients in which immunotherapy was performed (early withdrawal of CsA, DLI). Of the 30 patients who were treated only with allo-SCT, the average IL-12 levels of the patients who maintained CR were higher than that in the relapse group (P=0.0779). No correlation was observed between the development of acute GVHD or chronic GVHD and the IL-12 level. Of 9 patients who received immunotherapy after allo-SCT, IL-12 levels were significantly higher in those with a good response than in those who did not (P<C0.0389). Those former patients maintained this high level for a long period. After immunotherapy, IL-12 levels were significantly elevated in the patients who developed cGVHD (P=0.0201). These results indicate that IL-12 could induce an immunoreaction after allo-SCT and thus effect a cure for hematological malignancies.

公開者 千葉医学会
コンテンツの種類 雑誌掲載論文 Journal Article
ファイル形式 application/pdf
ISSN 03035476
NCID AN00142148
掲載誌情報 千葉医学雑誌 Vol.78 no.2 page.75-82 (20020401)
情報源 Chiba medical journal
言語 英語
著者版フラグ publisher

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