Partial Adrenalectomy in Patients with Primary Aldosteronism   :   原発性アルドステロン症における副腎部分切除術 

作成者 Horigome, Tohru, Nakada, Teruhiro
作成者の別表記 堀米, 亨, ホリゴメ, トオル, 中田, 瑛浩, ナカダ, テルヒロ
キーワード等 partial adrenalectomy, aldosteronism, mineralocorticoid function
日本十進分類法 (NDC) 490
内容 atients with primary aldosteronism due to unilateral and solitary adrenocortical aldosterone-producing adenoma (APA) underwent unilateral adrenalectomy or enucleation of adenoma (partial adrenalectomy). Five years after respective operations, the possibility of tumor recurrence from remnant adrenal tissues, hypothalamic-pituitary-adrenal axis function, and urinary concentrating ability were investigated to determine which method is preferable.Hypertension, hypokalemia and impaired urinary concentrating ability were improved to the same extent in the two groups. Mineralo-and glucocorticoid functions were well preserved in partially adrenalectomized patients. Remarkably low level of aldosterone production, but not cortisol production was noted in APA-adjacent tissues. Abnormal mineralocorticoid receptor-binding sites were normalized by each operation.These findings support the notion that partial adrenalectomy appears to be preferable in patients with primary aldosteronism. The likelihood of tumor recurrence from remnant ipsilateral adrenal gland appears to be lower in this operation method.
公開者 千葉医学会
コンテンツの種類 雑誌掲載論文 Journal Article
ファイル形式 application/pdf
ISSN 0303-5476
NCID AN00142148
掲載誌情報 千葉医学雑誌 Vol.83 no.3 page.83-90 (2007-06-01)
情報源 Chiba medical journal
言語 英語
関連情報 (URL)
著者版フラグ publisher

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